The Stooges play the roles of unsuccessful actors who have decided to end it all by jumping off a skyscraper. On top of the building, they discover three girls with an unsuccessful dancing act who have also decided to jump. The Stooges immediately fall in love with the girls. The six distraught lovers are still planning to jump when they suddenly hear piano music playing. They leave the ledge to go find the source of the music. On a lower floor they discover a piano-playing millionaire who is looking for a talented act. He promises them a significant amount of money if they are good. Their act is a success with the millionaire, and it looks like everything will end happily...until the devastating revelation at the end.
The millionaire has just promised to double their salaries when he says, "The way I throw my money around, I bet you think I'm crazy!" As if on cue, two men in white coats come to take him back to an asylum. He wants to go "by train," and one of them gives him a toy locomotive; as they escort him away he says, "Choo choo choo..." Moe moans, "He's as nutty as a nest of cuckoos!"
Rhythm and Weep was filmed near the end of Curly Howard's career. The 42-year-old comedian had suffered a series of minor strokes several months prior to filming, and his performances had been unpredictable. By the time of Rhythm and Weep, he had lost a considerable amount of weight, and lines had creased his baby face.
While director Edward Bernds devised ways to cover his illness, Jules White simply gave most of Curly's lines to Larry. In fact, Curly was so ill during production that he could no longer remember what few lines he had. To complete a scene, Moe would say Curly's lines to him, and then Curly would repeat them for the camera. Moe's son-in-law Norman Maurer was present during filming, and recalled Curly was hurting. "He was having trouble with his coordination," recalled Maurer. "He was supposed to pop pills in his mouth during the (doctor's office) scene, but the scene was switched to Moe putting the pills into Curly's mouth because of Curly's physical problems."